India-specific model developed to determine the age of a foetus

• BRIC-THSTI Faridabad and IIT Madras researchers have developed an India-specific model to determine the age of a foetus in a pregnant woman in the second and third trimesters precisely.
• Currently, the age of a foetus (gestational age, GA) is determined using a formula developed for Western populations and are likely to be erroneous when applied in the later part of pregnancy due to variations in the growth of the foetus in Indian population.
• The newly developed second and third-trimester GA formula, Garbhini-GA2, accurately estimates the age of a foetus for the Indian population, reducing error by almost three times. Accurate GA is necessary for the appropriate care of pregnant women and for determining precise delivery date.
• Ultrasound dating in early pregnancy is the standard of care for determining GA. However, a major proportion of women in India have their first ultrasound done in their second and third trimester of pregnancy. In these women, the application of Indian population-specific GA formulae, with better accuracy, can potentially improve pregnancy care leading to better outcomes.
• This accurate dating will also enhance the precision of epidemiological estimates for pregnancy outcomes in the country.
• Once validated in prospective pan-India cohorts, this Garbhini-GA2 can be deployed in clinics across India, improving the care delivered by obstetricians and neonatologists, thus reducing maternal and infant mortality rates in India.

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Published date : 26 Feb 2024 05:26PM